Growth Hormone Deficiency

Growth Hormone (HGH or human growth hormone as some people call it) is a crucial hormone for a healthy life. What surprises most people is the fact that growth hormone affects much more than just a child's height.

Serious problems relating to; heart strength, lung capacity, bone density, immune system function and much more can all be impacted by growth hormone deficiency.  The entire body is affected if a child is growth hormone deficient. Therefore, it is IMPORTANT to identify children with growth hormone deficiency early to avoid permanent delays and damage in addition to the potential loss of height.

Growth Hormone Deficiency is a treatable condition.

One cause of children's growth failure is Growth Hormone Deficiency. Growth hormone is secreted by the pituitary and is one of a number of hormones affecting a child's growth. Sometimes there is a deficiency of other pituitary hormones resulting in Hypopituitarism. However, for this segment we will restrict our discussion to growth hormone deficiency in children.

A growth hormone deficient child usually shows a growth pattern of less than 2 inches a year. In many cases the growth hormone deficient child will grow normally until the age of 2 or 3 and then begin to show signs of delayed growth. Other children will experience growth failure earlier or later than this age range. Though much smaller, these growth hormone deficient children have normal body proportions and often tend to look younger than their peers. Some may appear to be on the higher percentile in weight, though cases of Growth Hormone Deficiency have been diagnosed for children of low weight.

Testing

When a parent suspects growth failure of their child, they are often not immediately tested for Growth Hormone Deficiency. Previous growth measurements, when available, should be evaluated, a bone age (x-ray of a child's hand and wrist) taken and blood samples assessed for possible thyroid hormone deficiency.

Testing for Growth Hormone Deficiency will occur when other possibilities of short stature have been ruled out. A child's growth hormone secretion will be stimulated by one of several agents such as clonidine and Ldopa. The release of growth hormone may also be measured over a period of 8-12 hours, since growth hormone secretion varies throughout the day and is greatest after falling asleep.

Diagnosis & Treatment

Once diagnosed with Growth Hormone Deficiency, treatment is with human growth hormone, now available in unlimited quantities. Though every child may not react similarly to growth hormone treatment, the majority of children under therapy today reach a normal adult height or nearly their full growth potential. Growth hormone therapy is given by injection, either daily or several times per week. Parents are trained to give these injections and children, once they are comfortable with it, continue on their own.

Early diagnosis is extremely important for a growth hormone deficient child. To obtain the best results, a child must be diagnosed and treated at a relatively young age. Accurate annual measurements and plotting of a child's growth chart allows for identification of growth failure and treatment before the child's bones fuse. Once fusing has taken place, no additional growth is possible.

Short stature can be difficult for a child and their family. Many children much shorter than their peers experience both physical and emotional problems. Communicate with your child, offer assistance when necessary, but remember, act towards your child according to their age, not according to their size.

Psychological Issues

Psychosocial (how children emotionally adapt to social situations) issues of children with extreme short stature can be very traumatic for some children. And theories vary from place to place as to how much of an influence short stature plays in a persons life both physically and psychologically. Psychosocial aspects, influences and family factors all contribute to a healthy child. However, as parents, we all need to be keenly aware of potential problems.

People tend to judge others by what they wear, how they speak, what they know, and by how they look. Part of the judgement about "looks" is the assessment of height. We seem to judge age by height, "He looks like a five year old", people say, "She seems to be about ten years old". Having made this decision people proceed to act toward the other person, particularly if it is a child, as though they are actually as old as they appear.

For most normal statured children this poses no problems. But for short children who are growth delayed, it can make life difficult. It causes two sets of problems; it suggests to the child that he/she is younger than they are and allows for immature behavior. Second, it interferes with social maturation in the child because he/she will tend to behave in a fashion consistent with what adults seem to expect. Therefore, many short growth delayed children have trouble "acting their age". They become silly and prankish, playing the role of a "clown". This tendency to be immature was thought for a long time to be the major psychological difficulty facing short children, but recent studies have shown there may be others.

In the U.S. approximately 4 to 5% of school-age children show significant degrees of underachievement academically each year. Recent studies done in the National Cooperative Growth Study (NCGS) supported by Genentech, Inc., show that short children entering growth hormone treatment have a much higher rate of learning problems and social problems. About 18 to 20% have a learning skill deficit in arithmetic, spelling or reading. Another group has problems in social interactions and show behavioral problems such as shyness, withdrawal or attention deficits. These problems appear in children with different growth diagnoses and therefore cannot be due entirely to the social effects of being short. Parents should carefully consider how they will approach managing these potential difficulties.

There are several ways to help short children cope with their problems.

First, soon after diagnosis you should ask your pediatric endocrinologist or pediatrician who they would recommend to carry out psychological testing on your child. This is essential in order to know if there are problems in intelligence, academic achievement, learning disability, attention deficit disorders or behavior problems. A skilled pediatric or child psychologist, possibly the school psychologist, can evaluate for these types of problems and offer possible solutions. Also being in close touch with your child's school regarding academic progress or signs of social or behavior problems usually helps "head off" problems before they get out of hand.

Second, building your child's self-esteem is very important. Developing a strong positive self-image is every bit as important as building taller stature. Try to use every opportunity to praise and encourage, do not criticize, be sarcastic, or negative. Find your child's strengths and work to build on them. For example, most short children feel sure they can never be involved in sports. This is incorrect. There are many non-contact sports to become involved with, tennis, track, and swimming to name just a few. If your child has a sense of humor, develop it, praise it, and comment positively about it. If your child is creative, a writer, a poet, a musician; spend time supporting and enlarging these gifts. If your child is especially compassionate towards others, notice, report what you see, and admire the quality. Building positive self-esteem will help combat any negative effects brought about because of feeling different or rejected by others.

Finally, be sure you and your child fully understand what is to be expected from growth hormone therapy. Some studies suggest that children and parents have unrealistic expectations for the changes in height that therapy might bring. They expect too much, believing that treatment will make large differences in height immediately. This is not the case and can lead to some disappointments if these misconceptions are not quickly cleared up. Ask your pediatric endocrinologist or nurse about the treatment at each visit, make up a list of issues, be sure your child also has an opportunity to talk and ask  questions, even if they seem silly or stupid.

Growth Delayed Children Later In Life 

Researchers have followed the academic and vocational careers of several groups of patients who were growth hormone deficient as children, and for some the outlook is not entirely satisfactory.

Some reports on these young people indicate they do not perform well academically, do not go on to college or higher education, live at home with parents for extended periods of time, and may be unhappy in their social and work lives.

Although these problems are not seen in the majority of cases, they occur frequently enough to warrant concern by physicians, nurses and parents. It may be that growth hormone deficiency is associated with a lack of motivation and drive, or with a tendency to be shy and withdrawn. These characteristics could also be related to the problems of academic and social success. Whatever the cause, it is becoming clear that in order to better develop a successful adult life, children undergoing growth hormone treatment should receive support for a better, all-around outcome.

Suggested Reading

These books are not specifically aimed at parents of short children but have useful advice on raising psychologically healthy children.  1.“How to Raise Children's Self-Esteem” Harris Clemes and Reynold Bean Los Angeles. Sytern-Sloan, 1980  2.“How to Help Children With Common Problems” Charles E. Schaefer and Howard L. Millman New York. Van Nostrand Reinhold, 1984.

Contributing Medical Specialists

Richard A. Levy, M.D.
Pediatric Endocrinologist
Rush-Presbyterian St. Lukes Medical Center
Chicago, IL

Brian Stabler Ph.D.
Chapel Hill, NC

Resources

»  Download a printable version of the GHD brochure
»  Download a printable version of the Dental Problems Associated with Growth Hormone Deficiency brochure
»  Download a printable version of the Psychosocial Issues of Growth Delayed Children brochure
»  Download a printable version of the Frequently Asked Questions when Beginning Growth Hormone Therapy brochure
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»  Join our closed GHD Facebook group for parents. After you request to join, please message an admin to gain access or email Teresa at teresa@magicfoundation.org
»  Jamie's Story - A Mother's Journey about her Growth Hormone Deficient child
»  Would you like to speak to someone about GHD? If so, call The MAGIC Foundation at 800-3MAGIC3 or (630) 836-8200 or Email Us

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